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Early Serum Calcium and Late Parathyroid Hormone Increase With Magnesium Therapy

Thomas Wiegmann, MD, FRCP(C); Michael Kaye, MD, FRCP(C)

Arch Intern Med. 1977;137(7):953-955.

Abstract
A patient with short-bowel syndrome developed severe hypomagnesemia (0.2 mEq/liter) associated with symptomatic hypocalcemia (6.1 mg/100 ml). Parathyroid hormone (PTH) levels were normal but inappropriately low. During therapy with magnesium sulfate, an initial hypocalcemia was followed by a calcemic response without a change in PTH levels. This indicates improved bone responsiveness to circulating low levels of endogenous PTH with magnesium replenishment, which appears to be related to the restoration of magnesium-dependent cellular mechanisms. The additional observation of a slow and delayed increase in PTH, despite normal calcium levels, indicates improvement of hormone synthesis.

(Arch Intern Med 137:953-955, 1977)

Author Affiliations
From the Division of Nephrology, Montreal General Hospital.

Footnotes
Accepted for publication Oct 12, 1976.

Reprint requests to Division of Nephrology, 2nd Floor, Livingston Hall, 1650 Cedar Ave, Montreal, Quebec H3G 1A4 (Dr Wiegmann).

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