This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Clinical Manifestations After Renal Transplantation

Sakdidej Suwansirikul, MD; Nalini Rao, MD; John N. Dowling, MD; Monto Ho, MD

Arch Intern Med. 1977;137(8):1026-1029.

Abstract
Forty-seven patients who underwent renal transplants were followed clinically and were examined for serologic or virologic evidence of cytomegalovirus (CMV) infection. There were 18 cases of primary infection and ten cases of secondary infection. These findings were based on whether the patient was seronegative or seropositive prior to transplantation. Thirteen patients with primary infection and only one patient with secondary infection had two or more of the following manifestations that are temporally associated with laboratory evidence of infection: fever, leukopenia, atypical lymphocytes, lymphocytosis, hepatosplenomegaly, myalgia, arthralgia, and pneumonitis. Five patients with primary infections, one of whom died with disseminated disease, were recognized by attending physicians as having CMV disease. Since primary infection is thought to be largely due to virus transmitted by the kidney of a seropositive donor, it may be possible to prevent symptomatic primary infection by using only seronegative donors for seronegative recipients.

(Arch Intern Med 137:1026-1029, 1977)

Author Affiliations
From the Division of Infectious Diseases, Department of Medicine, School of Medicine, and the Department of Microbiology, Graduate School of Public Health (Dr Ho), University of Pittsburgh.

Footnotes
Accepted for publication Sept 27, 1976.

Reprint requests to Crabtree A-427, University of Pittsburgh, Pittsburgh, PA 15261 (Dr Ho).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Prophylaxis of Serious Cytomegalovirus Infection in Renal Transplant Candidates Using Live Human Cytomegalovirus Vaccine: Interim Results of a Randomized Controlled Trial
Brayman et al.
Arch Surg 1988;123:1502-1508.
ABSTRACT  

Disease due to Cytomegalovirus and Its Long-term Consequences in Renal Transplant Recipients: Correlation of Allograft Survival With Disease due to Cytomegalovirus and Rubella Antibody Level
Luby et al.
Arch Intern Med 1983;143:1126-1129.
ABSTRACT  

Unexplained Fever in Burn Patients due to Cytomegalovirus Infection
Deepe et al.
JAMA 1982;248:2299-2301.
ABSTRACT  

Guillain-Barrelike Polyneuropathy After Renal Transplant: Possible Association With Cytomegalovirus Infection
Bale et al.
Arch Neurol 1980;37:784-784.
ABSTRACT  

Live Cytomegalovirus Vaccination of Renal Transplant Candidates: A Preliminary Trial
GLAZER et al.
ANN INTERN MED 1979;91:676-683.
ABSTRACT  

Cytomegalovirus Vaccine in Renal Transplants
BETTS
ANN INTERN MED 1979;91:780-782.
ABSTRACT  

Cytomegalovirus Infection in Dialysis Patients and Personnel
TOLKOFF-RUBIN et al.
ANN INTERN MED 1978;89:625-628.
ABSTRACT