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Isoniazid ChemoprophylaxisAssociation With Detection and Incidence of Liver Toxicity
Col Richard B. Byrd, MC;
Maj Barry R. Horn, MC;
Col George A. Griggs, MC;
Maj David A. Solomon, MC
Arch Intern Med. 1977;137(9):1130-1133.
Abstract
The hepatotoxicity of isoniazid was studied in a double blind fashion in 120 adult patients receiving the drug for chemoprophylaxis. The incidence of abnormal SGOT values was significantly higher in those on the drug, 18.3% having elevated values as compared to 6.7% of those on placebo during the three-month study period. There was no statistical difference in the frequency of symptoms suggestive of liver diseases between the isoniazid and placebo groups. Furthermore, there was no significant relationship between symptoms and elevated SGOTs. Therefore, symptomatology would not appear to be a sensitive method for detecting early isoniazid liver toxicity. From available evidence, biochemical monitoring would appear to detect liver toxicity at an earlier and more reversible stage.
(Arch Intern Med 137:1130-1133, 1977)
Author Affiliations
USAF; USAF; USAF; USAF
From the Department of Pulmonary Diseases, USAF Medical Center, Scott, Scott AFB, Ill.
Footnotes
Accepted for publication Oct 13, 1976.
Reprint requests to Department of Pulmonary Diseases, USAF Medical Center, Scott, Scott AFB, IL 62225 (Dr Byrd).
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