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Effects on Alcohol Metabolism

Richard Levy, MD, MPH; Tom Elo, MD; Irwin B. Hanenson, MD

Arch Intern Med. 1977;137(9):1175-1177.

Abstract
This study was designed to determine the efficacy of the intravenous administration of fructose in the treatment of acute alcohol intoxication. The study was prospective and double-blind, with glucose serving as the control. Treatment with glucose and fructose was determined by random selection. Fructose administration did not alter the clinical status or rate of alcohol metabolism as reflected by the decline in serum concentration. In addition, a significant elevation (P <.05) in serum uric acid and lactate levels occurred in the patients receiving fructose. The results indicate that fructose is of no value in the treatment of acute alcohol intoxication, and produces metabolic abnormalities that could be harmful to the patient.

(Arch Intern Med 137:1175-1177, 1977)

Author Affiliations
From the Division of Emergency Medicine (Drs Levy and Elo) and the Departments of Medicine and Pathology (Dr Hanenson), University of Cincinnati Medical Center.

Footnotes
Accepted for publication Nov 1, 1976.

Reprint requests to Division of Laboratory Medicine, University of Cincinnati Medical Center, 234 Goodman St, Mont Reid 118, Cincinnati, OH 45229 (Dr Hanenson).

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