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Jose Barbosa, MD; Richard King, MD, PhD; Frederick C. Goetz, MD; Harriet Noreen; Edmond J. Yunis, MD

Arch Intern Med. 1978;138(1):90-93.

Abstract
HLA haplotypes in a kindred with a maturity-onset type of hyperglycemia in the young (MOHY) were studied. All diabetics had mild hyperglycemia of early onset, and the inheritance pattern suggested an autosomal dominant trait. Eight of 11 subjects with hyperglycemia shared haplotype A3, Bw15. When only this haplotype was considered, there appeared to be a significant association with hyperglycemia ² = 6.36). However, since both haplotypes in the proband could be associated with hyperglycemia (both proband's parents had hyperglycemia), the data for both haplotypes were combined, and analysis for an association between both haplotypes and hyperglycemia was not significant (² = 2.53). Linkage between a diabetes gene causing MOHY and the HLA, evaluated by lod score analysis, was suggested, but the values were not significant.

(Arch Intern Med 138:90-93, 1978)

Author Affiliations
From the Departments of Medicine (Drs Barbosa, Goetz, and King) and Pathology and Laboratory Medicine (Ms Noreen), University of Minnesota, Minneapolis; and Department of Pathology (Dr Yunis), Harvard University Medical School, Boston.

Footnotes
Accepted for publication March 15, 1977.

Presented in part at the 36th national meeting of the American Diabetes Association, San Francisco, June 20 to 22, 1976, and to the First Congress on HLA and Disease, Paris, June 23 to 25, 1976.

Reprint requests to University of Minnesota Hospitals, Department of Medicine, Box 504, Minneapolis, MN 55455 (Dr Barbosa).

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