This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Incidence in Patients Receiving Long-term Hemodialysis Therapy

Peter Gailiunas, Jr, MD; Manuel Dominguez-Moreno, MD; J. Michael Lazarus, MD; Edmund G. Lowrie, MD; Michael N. Gottlieb, MD; John P. Merrill, MD

Arch Intern Med. 1978;138(11):1621-1624.

Abstract
Twenty-three patients on long-term hemodialysis regimens who received gentamicin sulfate were reviewed retrospectively to assess the incidence of ototoxicity and to identify potential risk factors. Dosage of gentamicin sulfate was 1.0 to 1.5 mg/kg intravenously three times weekly. Serum gentamicin levels were monitored in 21 cases. Seven patients developed signs and symptoms of vestibular dysfunction.

Statistically significant differences were found between the ototoxic and nonototoxic groups with respect to age (P <.001), total dose (milligrams per kilogram) (P <.001), and duration of therapy (P <.001). The total dose per kilogram of body weight contributed most heavily to ototoxicity, and regression analysis suggests that the critical cumulative dose is about 17.5 mg/kg. The two groups did not differ with respect to mean peak and valley serum levels.

We conclude that this population is at high risk of developing gentamicin-related vestibular dysfunction specifically when the cumulative dose exceeds 17.5 mg/kg.

(Arch Intern Med 138:1621-1624, 1978)

Author Affiliations
From the Departments of Medicine of Harvard Medical School and the Peter Bent Brigham Hospital, Boston. Dr Gailiunas is now with the Southwestern Medical School, Dallas.

Footnotes
Accepted for publication Feb 1, 1978.

Reprint requests to Department of Medicine, Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX 75235 (Dr Gailiunas).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Current Management of Vascular Access
Allon
CJASN 2007;2:786-800.
ABSTRACT | FULL TEXT  

Administration of Tobramycin in the Beginning of the Hemodialysis Session: A Novel Intradialytic Dosing Regimen
Kamel Mohamed et al.
CJASN 2007;2:694-699.
ABSTRACT | FULL TEXT  

Vestibulo-ocular Physiology Underlying Vestibular Hypofunction
Schubert and Minor
ptjournal 2004;84:373-385.
ABSTRACT | FULL TEXT