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Darrell Apple, MD; Kenneth Kreines, MD; J. Park Biehl, MD

Arch Intern Med. 1978;138(11):1713-1714.

Abstract
The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) occurred during an excerbation of multiple sclerosis (MS). Rapid symptomatic improvement occurred with correction of the hyponatremia. Although the pathophysiology responsible for development of the SIADH in this patient is unknown, CNS involvement by MS is a likely explanation.

(Arch Intern Med 138:1713-1714, 1978)

Author Affiliations
From the Department of Medicine, Division of Metabolism (Drs Apple and Kreines), and Department of Neurology (Dr Biehl), University of Cincinnati College of Medicine.

Footnotes
Accepted for publication June 26, 1978.

Reprint requests to 5564 Medical Science Bldg, 231 Bethesda Ave, Cincinnati, OH 45267 (Dr Kreines).

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