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Atypical Seizure Manifestation

Edra B. Weiss, MD; Phillip Forman, MD; Ira M. Rosenthal, MD

Arch Intern Med. 1978;138(11):1743-1744.

Abstract
A 17-year-old boy with partial hypoxanthine-guanine phosphoribosyl transferase deficiency developed a hypersensitivity reaction to allopurinol. The reaction was manifested by the development of bizarre, atypical seizures. The patient had been neurologically normal prior to the reaction. Seizures disappeared following discontinuation of allopurinol therapy. Allopurinol apparently can cause a diffuse vasculitis involving cerebral vessels after many years of therapy, resulting in atypical seizures.

(Arch Intern Med 138:1743-1744, 1978)

Author Affiliations
From the Departments of Pediatrics (Drs Weiss and Rosenthal) and Neurology (Dr Forman), Abraham Lincoln School of Medicine, University of Illinois College of Medicine, Chicago.

Footnotes
Accepted for publication April 17, 1978.

Reprint requests to Department of Pediatrics, Abraham Lincoln School of Medicine, University of Illinois College of Medicine, 840 S Wood St, Chicago, IL 60612 (Dr Rosenthal).

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