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Hyperchloremia and Negative Anion Gap Associated With Polymyxin B Administration
Daniel T. O'Connor, MD;
Richard A. Stone, MD
Arch Intern Med. 1978;138(3):478-480.
Abstract
A patient receiving polymyxin B sulfate intravenously for Gram-negative bacteremia developed progressive hyperchloremia and a negative "anion gap." Both abnormalities resolved following discontinuation of the drug. In vitro investigation suggested that the electrolyte abnormalities resulted from the polycationic properties of polymyxin B.
(Arch Intern Med 138:478-480, 1978)
Author Affiliations
From the Division of Nephrology, Departments of Medicine, University of California, San Diego, School of Medicine and the Veterans Administration Hospital, San Diego.
Footnotes
Accepted for publication April 1, 1977.
Reprint requests to Division of Nephrology, Veterans Administration Hospital, 3350 La Jolla Village Dr, San Diego, CA 92161 (Dr Stone).
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