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Report of Immune-Mediated Events in Skin and Brain

James A. Davis, MD; Michael H. Weisman, MD; David H. Dail, MD

Arch Intern Med. 1978;138(3):480-483.

Abstract
A patient with subacute bacterial endocarditis, who had a prosthetic mitral valve, exhibited hypocomplementemia, mixed (IgG, IgM) cryoglobulinemia, and widespread dermal vasculitis with IgM deposited at the dermoepidermal junction. Postmortem findings included immune-complex glomerulonephritis and deposits of IgG in the choroid plexus. These findings are consistent with a generalized vasculitis, which may be mediated by circulating immune complexes; basement membrane localization of immune complexes to the skin and choroid plexus appears not to be specific for systemic lupus erythematosus, as has been previously thought, but may represent the general phenomenon of immune-mediated pathogenesis.

(Arch Intern Med 138:480-483, 1978)

Author Affiliations
From the Departments of Medicine (Drs Davis and Weisman) and Pathology (Dr Dail), University of California Medical Center, San Diego.

Footnotes
Accepted for publication June 1, 1977.

Reprint requests to Rheumatology Division, University Hospital, University of California Medical Center, 225 W Dickinson St, San Diego, CA 92103 (Dr Weisman).

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