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Incidence of Pituitary Tumors Following AdrenalectomyA Long-Term Follow-up Study of Patients Treated for Cushing's Disease
Kenneth L. Cohen, MD;
Robert H. Noth, MD;
Terri Pechinski, RN
Arch Intern Med. 1978;138(4):575-579.
Abstract
The long-term follow-up of 21 patients who had undergone bilateral adrenalectomy for Cushing's disease has revealed eight definite and two suspected cases of pituitary tumors. The average time from adrenalectomy to the diagnosis of the pituitary tumor was 6 1/2 years, with a range of 1 1/2 to 12 years. The incidence of tumors in this study (38%) is higher than that reported by others and may reflect (1) that none of these patients received pituitary irradiation in addition to adrenalectomy, (2) the length of follow-up, and (3) the high index of suspicion and early diagnosis of pituitary tumors in recent years. These data raise the question of whether bilateral adrenalectomy alone is an acceptable form of therapy for Cushing's disease. For patients treated in this way, a life-long commitment should be made to undergo annual reexamination for the possible occurrence of a pituitary neoplasm.
(Arch Intern Med 138:575-579, 1978)
Author Affiliations
From the Department of Medicine, Yale University School of Medicine, New Haven, Conn.
Footnotes
Accepted for publication April 21, 1977.
Reprint requests to Department of Medicine, Yale University School of Medicine, New Haven, CT 06510 (Dr Cohen).
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