This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (98)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Review of 958 Cases

John S. Kintzer, Jr, MD; Edward C. Rosenow III, MD; Robert A. Kyle, MD

Arch Intern Med. 1978;138(5):727-730.

Abstract
Review of the records of 958 patients with multiple myeloma disclosed thoracic skeletal or pleuropulmonary abnormalities or both in 443 patients (46%). The abnormalities were an initial finding on 25% of the chest roentgenograms. The most common finding, exclusive of plasmacytomas, was thoracic skeletal abnormality in 28% (the initial finding in 15%)—osteolytic lesions being the most frequent abnormality. Localized or diffuse pulmonary infiltrates, most often caused by infections, were present in 10%. Four patients had a diffuse infiltrate thought to be caused by a plasma cell infiltrate (proven in one). In 113 patients, plasmacytomas were seen (intramedullary 102, extramedullary 11)—as an initial finding in 8%. Fifty-eight patients (6%) had pleural effusions. Eight patients with pleural effusion caused by myeloma are added to the eight cases reported in the literature.

(Arch Intern Med 138:727-730, 1978)

Author Affiliations
From the Mayo Clinic and Mayo Foundation, Rochester, Minn.

Footnotes
Accepted for publication May 13, 1977.

Reprint requests to Mayo Clinic, 200 First St SW, Rochester, MN 55901 (Dr Rosenow).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Acute respiratory distress syndrome due to pulmonary involvement by neoplastic plasma cells in multiple myeloma
Marmor et al.
Thorax 2006;61:455-456.
ABSTRACT | FULL TEXT  

MYELOMATOUS PLEURAL EFFUSION AND AIRWAY COMPRESSION COMPLICATING MULTIPLE MYELOMA
Rowe
Chest Meeting 2005;128:429S-430S.
ABSTRACT | FULL TEXT  

Primary Solitary Endobronchial Plasmacytoma
Edelstein et al.
Ann. Thorac. Surg. 2004;78:1448-1449.
ABSTRACT | FULL TEXT  

Pleural Effusions in Hematologic Malignancies
Alexandrakis et al.
Chest 2004;125:1546-1555.
ABSTRACT | FULL TEXT  

Hematologic Malignancies With Extramedullary Spread of Disease: Case 1. Multiple Myeloma With Extramedullary Involvement of the Pleura and Testes
Giuliani et al.
JCO 2003;21:1887-1888.
FULL TEXT  

Aggressive Phase of Multiple Myeloma With Pulmonary Plasma Cell Infiltrates
Garewal and Durie
JAMA 1982;248:1875-1876.
ABSTRACT  

Flail Chest and Multiple Myeloma
Mansouri
JAMA 1980;243:1036-1036.
ABSTRACT