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Renal and Hepatic Toxic Reactions

Alexander C. Chester, MD; Louis H. Diamond, MD; George E. Schreiner, MD

Arch Intern Med. 1978;138(7):1138-1139.

Abstract
Salicylazosulfapyridine has been used for a number of years as therapy for ulcerative colitis. Reported toxicities are usually minor. This case report represents an acute allergic reaction to the drug, characterized by fever, rash, eosinophilia, nephritis, and hepatitis. Resolution occurred with discontinuation of salicylazosulfapyridine. Although similar reactions have been reported with the antimicrobial sulfonamides, none has been fully described with salicylazosulfapyridine, a combination of a sulfonamide and salicylate.

(Arch Intern Med 138:1138-1139, 1978)

Author Affiliations
From the Georgetown University Department of Medicine, Division of Nephrology, DC General Hospital, Washington, DC; and the Department of Medicine, Division of Nephrology, Georgetown University Hospital, Washington, DC.

Footnotes
Accepted for publication Aug 25, 1977.

Reprint requests to Department of Medicine, Georgetown University Hospital, 3800 Reservoir Rd, NW, Washington, DC 20007 (Dr Chester).

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