This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (74)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Prospective Evaluation

David M. Margolis, MD; Jack L. Saylor, MD; Guillermo Geisse, MD; Kathryn DeSchryver-Kecskemeti, MD; Herschel R. Harter, MD; Gary R. Zuckerman, DO

Arch Intern Med. 1978;138(8):1214-1217.

Abstract
A prospective study was undertaken to determine the incidence of upper gastrointestinal disease in 85 chronic renal failure (CRF) patients on hemodialysis. Upper gastrointestinal x-rays were obtained for 83 patients, and enlarged gastric and duodenal folds were seen in 12% (10/83) and 42% (35/83) of the cases, respectively. Panendoscopy performed on 60 persons revealed gastritis in 22% (13/60), nodular duodenitis in 60% (35/ 60), and esophagitis in 13% (8/60). No peptic ulcers were identified either radiologically or endoscopically. Pathologic examination of mucosal biopsy specimens demonstrated gastritis in 46% (21/46) and duodenitis in 43% (22/51) of patients. A highly significant correlation was found between endoscopic and radiologic duodenitis (P <.0001) and also between endoscopic and pathologic gastritis (P <.05), but not between endoscopic and pathologic duodenitis. We have demonstrated a high incidence of mucosal inflammation but not ulcer disease in CRF patients. These lesions may predispose these individuals to gastrointestinal bleeding following renal transplantation.

(Arch Intern Med 138:1214-1217, 1978)

Author Affiliations
From the Department of Medicine (Drs Margolis, Saylor, Harter, and Zuckerman), Gastroenterology and Renal Divisions, Department of Pathology (Dr DeSchryver—Kecskemeti), and the Mallinckrodt Institute of Radiology (Dr Geisse), Barnes Hospital, Washington University School of Medicine, St Louis.

Footnotes
Accepted for publication Dec 14, 1977.

Reprint requests to Division of Gastroenterology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110 (Dr Zuckerman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Outcome of Patients With End-Stage Renal Disease Admitted to the Intensive Care Unit
Dara et al.
Mayo Clin Proc. 2004;79:1385-1390.
ABSTRACT  

Estrogen-Progesterone Therapy for Bleeding Gastrointestinal Telangiectasias in Chronic Renal Failure: An Uncontrolled Trial
BRONNER et al.
ANN INTERN MED 1986;105:371-374.
ABSTRACT  

Gastrointestinal Telangiectasias: A Source of Bleeding in Patients Receiving Hemodialysis
Dave et al.
Arch Intern Med 1984;144:1781-1783.
ABSTRACT  

Host Defenses and Immunologic Alterations Associated with Chronic Hemodialysis
GOLDBLUM and REED
ANN INTERN MED 1980;93:597-613.
ABSTRACT