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Basidiobolus haptosporus

David L. Dworzack, MD; Allan S. Pollock, MD; Glenn R. Hodges, MD; William G. Barnes, PhD; Libero Ajello, PhD; Arvind Padhye, PhD

Arch Intern Med. 1978;138(8):1274-1276.

Abstract
Basidiobolus haptosporus is known to cause subcutaneous zygomycosis in tropical Africa and Asia. We cared for a 49-year-old hyperglycemic, asplenic man who had never traveled outside the United States and who was seen initially for a painless palatal ulcer with cutaneous hypesthesia of the right cheek and upper lip. An invasive process involved the right middle nasal turbinate, maxillary antrum, maxillary division of the trigeminal nerve, and bony palate. Histological examination of biopsy tissue showed necrotizing granulomata with broad, nonseptate hyphae. Basidiobolus haptosporus was cultured from this tissue. Various laboratory studies revealed no immunologic defect and his lesions responded to therapy with amphotericin B. To our knowledge, this represents the first case of zygomycosis caused by B haptosporus in the Americas and the first culture-documented case of invasive mycosis caused by this mold.

(Arch Intern Med 138:1274-1276, 1978)

Author Affiliations
From the Medical (Drs Hodges and Dworzack) and Laboratory (Dr Barnes) Services, Veterans Administration Hospital, Kansas City, the Departments of Medicine (Drs Hodges, Dworzack, and Pollock) and Pathology (Dr Barnes), College of Health Sciences, University of Kansas Medical Center, Kansas City, and the Mycology Division, Center for Disease Control, Public Health Service, US Department of Health, Education, and Welfare, Atlanta (Drs Ajello and Padhye).

Footnotes
Accepted for publication Jan 25, 1978.

Read before the 77th Annual Meeting, American Society for Microbiology, New Orleans, May 10, 1977.

Reprint requests to Medical Service (111), Veterans Administration Hospital, 4801 Linwood Blvd, Kansas City, MO 64128 (Dr Hodges).

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