This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (16)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Peter W. Wilson, MD; Ronald B. Easley, PhD, MD; Franklyn F. Bolander, PhD, MD; Charles B. Hammond, MD

Arch Intern Med. 1978;138(8):1276-1277.

Abstract
A 21-year-old man demonstrated septo-optic dysplasia. Optic and retinal colobomas were present and panhypopituitarism was documented. Releasing hormone studies showed partial luteinizing hormone (LH) response and no follicle-stimulating hormone response to administration of gonadorelin (LH-releasing hormone); thyroid-stimulating hormone (TSH) and prolactin levels were increased normally after administration of protirelin (thyrotropin-releasing hormone). The LH, TSH, and prolactin responses are believed to be evidence of intact pituitary function and suggest that a hypothalamic defect accounts for the hypopituitarism.

(Arch Intern Med 138:1276-1277, 1978)

Author Affiliations
From the Division of Endocrinology, Department of Medicine (Drs Wilson, Easley, and Bolander), and the Department of Obstetrics and Gynecology (Dr Hammond), Duke University Medical Center, Durham, NC.

Footnotes
Accepted for publication Aug 15, 1977.

Reprint requests to National Heart, Lung, and Blood Institute, Federal Building, Room 2C08, Bethesda, MD 20014 (Dr Wilson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Review Article: Optic Nerve Hypoplasia: A Review
Ouvrier and Billson
J Child Neurol 1986;1:181-188.
ABSTRACT  

Review Article: Holoprosencephaly and Related Midline Cerebral Anomalies: A Review
Leech and Shuman
J Child Neurol 1986;1:3-18.
ABSTRACT  

Hypothalamic-Pituitary Function in Children With Optic Nerve Hypoplasia
Costin and Murphree
Arch Pediatr Adolesc Med 1985;139:249-254.
ABSTRACT  

The Endocrine Spectrum of Septo-optic Dysplasia
Izenberg et al.
CLIN PEDIATR 1984;23:632-636.
ABSTRACT  

Septo-optic Dysplasia and Median Cleft Face Syndrome in a Patient With Isolated Growth Hormone Deficiency and Hyperprolactinemia
Stewart et al.
Arch Pediatr Adolesc Med 1983;137:484-487.
ABSTRACT