This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (112)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Richard P. Wedeen, MD; Dipak K. Mallik, MD; Vecihi Batuman, MD

Arch Intern Med. 1979;139(1):53-57.

Abstract
Reduced glomerular filtration rates (GFR < 90 ml/min/ 1.73 sq m) were found in 21 of 57 lead workers in whom excessive body lead burdens had been shown by the urinary excretion of more than 1,000 µg of lead per day during an edetate disodium calcium lead-mobilization test. In 12 patients, renal biopsies confirmed the diagnosis of occupational lead nephropathy and further excluded other possible causes of kidney disease. Glomerular and tubular immunoglobulin deposition in seven of eight biopsy specimens examined by immunofluorescent microscopy raises the possibility that an autoimmune response may contribute to the interstitial nephritis of occupational lead nephropathy. The GFR increased 20% or more in four of eight patients treated with 1 g of edetate disodium calcium three times weekly for from six to 50 months, further confirming the diagnosis of lead nephropathy and indicating a favorable response to prolonged chelation therapy.

(Arch Intern Med 139:53-57, 1979)

Author Affiliations
From the Department of Medicine, College of Medicine and Dentistry of New Jersey-New Jersey Medical School, Jersey City Medical Center, Jersey City.

Footnotes
Accepted for publication May 17, 1978.

Reprint requests to Veterans Administration Hospital, East Orange, NJ 07019 (Dr Wedeen).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease
Roncal et al.
Am. J. Physiol. Renal Physiol. 2007;293:F1391-F1396.
ABSTRACT | FULL TEXT  

Confounding of the Relation between Homocysteine and Peripheral Arterial Disease by Lead, Cadmium, and Renal Function
Guallar et al.
Am J Epidemiol 2006;163:700-708.
ABSTRACT | FULL TEXT  

Stem Cells of Aging Donors--Insufficient Capacity to Repair Causes Progression of Atherosclerosis in the Recipient: Molecular Evidence for Arterial Repair in Atherosclerosis. Proc Natl Acad Sci U S A 102: 16789-16794, 2005
Karra et al.
J. Am. Soc. Nephrol. 2006;17:317-322.
FULL TEXT  

Environmental Exposure to Lead and Progression of Chronic Renal Diseases: A Four-Year Prospective Longitudinal Study
Yu et al.
J. Am. Soc. Nephrol. 2004;15:1016-1022.
ABSTRACT | FULL TEXT  

Associations of lead biomarkers with renal function in Korean lead workers
Weaver et al.
Occup. Environ. Med. 2003;60:551-562.
ABSTRACT | FULL TEXT  

Blood Lead Level Is Associated With Elevated Blood Pressure in Blacks
Vupputuri et al.
Hypertension 2003;41:463-468.
ABSTRACT | FULL TEXT  

Environmental Lead Exposure and Progression of Chronic Renal Diseases in Patients without Diabetes
Lin et al.
NEJM 2003;348:277-286.
ABSTRACT | FULL TEXT  

Bone Lead Concentrations Assessed by in Vivo X-Ray Fluorescence
Ambrose et al.
Clin. Chem. 2000;46:1171-1178.
ABSTRACT | FULL TEXT  

Lead Stimulates Lymphocyte Proliferation Through Enhanced T Cell-B Cell Interaction
Razani-Boroujerdi et al.
J. Pharmacol. Exp. Ther. 1999;288:714-719.
ABSTRACT | FULL TEXT  

Factors Influencing Bone Lead Concentration in a Suburban Community Assessed by Noninvasive K X-ray Fluorescence
Kosnett et al.
JAMA 1994;271:197-203.
ABSTRACT  

Adult Chronic Lead Intoxication: A Clinical Review
Balestra
Arch Intern Med 1991;151:1718-1720.
ABSTRACT  

Effect of Occupational Lead Exposure on Serum 1,25-dihydroxyvitamin D Levels
Mason et al.
Hum Exp Toxicol 1990;9:29-34.
ABSTRACT  

Acute-Subacute Lead Poisoning: Clinical Findings and Comparative Study of Diagnostic Tests
Carton et al.
Arch Intern Med 1987;147:697-703.
ABSTRACT  

Chelation Therapy in Lead Nephropathy Questioned-Reply
Germain
Arch Intern Med 1985;145:1927-1927.
ABSTRACT  

Failure of Chelation Therapy in Lead Nephropathy
Germain et al.
Arch Intern Med 1984;144:2419-2420.
ABSTRACT  

Nephrology: An Annotated Bibliography of Recent Literature: References to Journal Articles and Other Papers
NEPHROLOGY COMMITTEE
ANN INTERN MED 1983;98:563-568.
ABSTRACT  

Lead enhancement of lithium-induced polydipsia
Wedeen
Science 1979;205:725-726.