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Leukopenia and HypoxemiaUnrelated Effects of Hemodialysis
Francis Dumler, MD;
Nathan W. Levin, MB, FCP(SA)
Arch Intern Med. 1979;139(10):1103-1106.
Abstract
Hemodialysis-induced hypoxemia has been attributed to membrane-related complement activation leading to pulmonary leukostasis and to hypoventilation secondary to carbon dioxide losses via the dialyzer. We have separately assessed the role of membrane- and dialysis-related factors by using different dialyzers and sequential ultrafiltration and hemodialysis. Hemodialysis with first-use cellulose dialyzers produced both leukopenia and hypoxemia. With reused cellulose and polyacrylonitrile dialyzers, hypoxemia still occurred, but without leukopenia. Ultrafiltration produced leukopenia and no changes in Pao2; during the subsequent hemodialysis, hypoxemia developed as the leukocyte count increased by 50%. Our data indicate that leukopenia and hypoxemia are unrelated effects of hemodialysis, and favor hypoventilation as the major determinant of hypoxemia during hemodialysis.
(Arch Intern Med 139:1103-1106, 1979)
Author Affiliations
From the Division of Nephrology, Department of Medicine, Henry Ford Hospital, Detroit.
Footnotes
Accepted for publication April 10, 1979.
Reprint requests to Division of Nephrology, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202 (Dr Dumler).
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