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Gershon W. Hepner, MD; Inder J. Chopra, MD

Arch Intern Med. 1979;139(10):1117-1120.

Abstract
Levels of serum triiodothyronine (T₃), reverse triiodothyronine (rT₃), and thyroxine (T₄) were determined in 29 patients with alcoholic cirrhosis, seven patients with acute hepatitis, and 14 control patients hospitalized for chronic disease. Serum T₃ levels were decreased significantly and serum rT₃ levels increased significantly in the patients with alcoholic cirrhosis. Serum T₃ and T₄ levels were lower and rT₃ levels higher in the cirrhotic patients who died within three months of the study compared with those who survived. A combination of prothrombin time, aminopyrine breath test results, and rT₃ and T₃ determinations gave significant predictive information about survival in patients with cirrhosis. The data suggest that assay of serum thyroid hormone levels together with prothrombin time and the aminopyrine breath test may be helpful in assessing the course and prognosis of patients with liver disease.

(Arch Intern Med 139:1117-1120, 1979)

Author Affiliations
From the Departments of Medicine, Harbor/UCLA Medical Center, Torrance, Calif (Dr Hepner), and UCLA Center for Health Sciences, Los Angeles (Dr Chopra).

Footnotes
Accepted for publication March 20, 1979.

Reprints not available.

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