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Therapy of Primary Amyloidosis With Melphalan and Prednisone
Richard S. Schwartz, MD;
James R. Cohen, MD;
Stanley L. Schrier, MD
Arch Intern Med. 1979;139(10):1144-1147.
Abstract
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Two patients with progressive primary amyloidosis, monoclonal serum and urinary proteins, multiple organ involvement, and nephrotic syndrome were treated with melphalan and prednisone for one year. In one patient, splenomegaly and nephrotic syndrome rapidly responded to therapy but massive hepatomegaly responded slowly, requiring 15 months' time for normalization of size. Results of liver function tests, although improved, remained abnormal, and amyloid deposits remained in the marrow. A second patient also demonstrated dramatic diminution in proteinuria and improvement in liver function abnormalities, but macroglossia persisted. These observations suggest that amyloid organ involvement may be reversible with differences in organ responsiveness to chemotherapy. An empirical trial of chemotherapy may be indicated in some patients with progressive primary amyloidosis, and therapy may need to be continued for a prolonged period of time before seeing an effect.
(Arch Intern Med 139:1144-1147, 1979)
Author Affiliations
From the Division of Hematology, Department of Medicine, Stanford (Calif) University School of Medicine.
Footnotes
Accepted for publication March 29, 1979.
Reprint requests to Division of Hematology, Room S161, Stanford Medical Center, Stanford, CA 94305 (Dr Schrier).
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