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Cardiac Findings in Charcot-Marie-Tooth DiseaseA Prospective Study of 68 Patients
Jeffrey M. Isner, MD;
Rollin J. Hawley, MD;
Alan M. Weintraub, MD;
W. King Engel, MD
Arch Intern Med. 1979;139(10):1161-1165.
Abstract
Charcot-Marie-Tooth disease (peroneal muscular atrophy) has been reported to cause cardiac arrhythmias and conduction disturbances in association with peripheral muscle atrophy. To establish more accurately the frequency of such cardiac disorders in this disease, 68 patients with Charcot-Marie-Tooth disease were evaluated prospectively for evidence of cardiac involvement. Cardiac findings were limited to five patients with conduction defects, two patients with supraventricular tachycardia, two patients with ischemic heart disease, and 20 with mitral valve prolapse. The frequency of each of the abnormal cardiac findings, with the possible exception of mitral valve prolapse, did not exceed the known frequency of these abnormalities in the population at large. The low incidence of cardiac involvement in patients with Charcot-Marie-Tooth disease may be helpful in distinguishing this disorder from Friedreich's ataxia, an entity that may mimic Charcot-Marie-Tooth disease but that is frequently associated with heart disease.
(Arch Intern Med 139:1161-1165, 1979).
Author Affiliations
From the Division of Cardiology, Department of Medicine (Drs Isner and Weintraub), and the Department of Neurology (Dr Hawley), Georgetown University Medical Center, Washington, DC, and the Medical Neurology Branch, National Institutes of Health (Dr Engel), Bethesda, Md.
Footnotes
Accepted for publication May 7, 1979.
Reprint requests to Cardiology Division, Tufts-New England Medical Center Hospital, 171 Harrison Ave, Boston, MA 02111 (Dr Isner).
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