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Cerebrospinal Fluid Lymphocyte Transformations in Meningitis
Joseph F. Plouffe, MD;
Joseph Silva, MD;
Robert Fekety, MD;
Ian Baird, MB, ChB
Arch Intern Med. 1979;139(2):191-194.
Abstract
Cerebrospinal fluid lymphocytes from 13 patients with nonsuppurative meningitis were cultured with antigens derived from Mycobacterium tuberculosis, Sporotrichum schenckii, and herpes simplex. When CSF lymphocytes from five patients with infections associated with these organisms were incubated with "correct" antigen there was increased incorporation of thymidine. The levels were higher than those seen when the cells were incubated with different antigens or when CSF lymphocytes from patients with other causes for their meningitis were cultured with these antigens. A compartmentalization of antigen-specific cells was suggested as CSF lymphocytes had greater stimulation than did peripheral blood lymphocytes from the same patient when incubated with the correct antigen. Transformational assays of CSF lymphocytes may provide a valuable diagnostic aid in certain cases of chronic meningitis.
(Arch Intern Med 139:191-194, 1979)
Author Affiliations
From the Departments of Medicine, The Ohio State University, Columbus (Dr Plouffe); University of Michigan, Ann Arbor (Drs Silva and Fekety); and Riverside Methodist Hospital, Columbus, Ohio (Dr Baird).
Footnotes
Accepted for publication Sept 8, 1978.
Reprint requests to Department of Medicine, N-1135 University Hospital, 410 W Tenth Ave, Columbus, OH 43210 (Dr Plouffe).
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