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Detection by Gallium 67 Imaging in the Transplant Patient

Isam A. Hamed, MD; James E. Wenzl, MD; Joe C. Leonard, MD; Geoffrey P. Altshuler, MD; James A. Pederson, MD

Arch Intern Med. 1979;139(3):286-288.

Abstract
Cytomegalovirus (CMV) infection is a frequent complication during the first few months following renal transplantation. The diagnosis is sometimes difficult but may be made by viral culture, a fourfold rise in the CMV antibody titer, or by demonstration of the CMV inclusions in the affected tissue. An increased pulmonary uptake of gallium citrate Ga 67 has been demonstrated following renal transplantation in two patients, each of whom had a fourfold rise in CMV complement fixing antibody titer, one of whom additionally had CMV inclusion bodies in a lung biopsy specimen prior to clinical or radiological demonstration of the pulmonary involvement. Gallium imaging, therefore, appears to be a valuable noninvasive test for early diagnosis of CMV pulmonary infections.

(Arch Intern Med 139:286-288, 1979)

Author Affiliations
From the Nephrology Section, Departments of Medicine (Drs Hamed and Pederson) and Pediatrics (Dr Wenzl), and Departments of Radiological Sciences (Dr Leonard) and Pathology (Dr Altshuler), University of Oklahoma Health Sciences Center, Oklahoma City.

Footnotes
Accepted for publication Oct 5, 1978.

Reprint requests to Department of Pediatrics, Oklahoma Children's Memorial Hospital, PO Box 26901, Oklahoma City, OK 73126 (Dr Wenzl).

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