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Failure of Trimethoprim/ Sulfamethoxazole in Invasive Nocardia asteroides Infection
P. Jan Geiseler, MD;
Frank Check, MD;
Francois Lamothe, MD;
Burton R. Andersen, MD
Arch Intern Med. 1979;139(3):355-356.
Abstract
A case of pulmonary nocardiosis occurred with progressive involvement of the pleura, pericardium, mediastinum, and sternum. Surgical resection and drainage procedures followed by administration of the drug combination, trimethoprim/sulfamethoxazole, over a six-month period led to clinical recovery. Discontinuation of drug therapy, however, was followed by relapse and further invasion by the same organism. A literature survey of Nocardia asteroides infections treated with trimethoprim/sulfamethoxazole disclosed that posttreatment follow-up is often too brief or unknown, making the ultimate success of therapy uncertain.
(Arch Intern Med 139:355-356, 1979)
Author Affiliations
From the Section of Infectious Diseases, Department of Medicine, Abraham Lincoln School of Medicine and the West Side Veterans Administration Hospital, Chicago.
Footnotes
Accepted for publication Oct 24, 1978.
Reprint requests to Section of Infectious Diseases, West Side Veterans Administration Hospital, 820 S Damen Ave, MP 151, Chicago, IL 60680 (Dr Andersen).
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ABSTRACT
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