This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (25)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Case of Sequential Drug Interactions

Dennis J. Chapron, MS; David Mumford, MD; Gerald I. Pitegoff, MD

Arch Intern Med. 1979;139(3):363-365.

Abstract
Accelerated quinidine metabolism was observed in a 94-year-old woman also receiving daily doses of digoxin and pentobarbital sodium. Discontinuation of pentobarbital produced a sharp increase in serum digoxin concentrations coupled with symptoms highly suggestive of digoxin toxicity. Associated with these findings was 3.8-fold increase in quinidine half-life.

These data seemed consistent with an interaction between quinidine and digoxin that was precipitated by pentobarbital withdrawal.

(Arch Intern Med 139:363-365, 1979)

Author Affiliations
From the School of Pharmacy, University of Connecticut, Storrs (Mr Chapron), and the Hebrew Home for the Aged, Hartford, Conn (Drs Mumford and Pitegoff).

Footnotes
Accepted for publication Oct 11, 1978.

Reprint requests to Department of Pharmacy, Univeristy of Connecticut Health Center, Farmington, CT 06032 (Mr Chapron).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?