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Liver Disease in Early Syphilis
David Campisi, MD;
Charles Whitcomb, MD
Arch Intern Med. 1979;139(3):365-366.
Abstract
Atypical manifestations of early syphilis, although uncommon, may represent diagnostic difficulties and delay therapy. We describe two cases of hepatitis complicating early syphilis. Clues to the diagnosis of early syphilitic hepatitis include the presence of perianal lesions and disproportionate increases in the serum alkaline phosphatase level. Biopsy results were nonspecific. The major differential diagnostic consideration is hepatitis B with false-positive serologic findings. The abnormalities of liver function respond to standard therapy for secondary syphilis. Follow-up of patients and their contacts is essential.
(Arch Intern Med 139:365-366, 1979)
Author Affiliations
From the Department of Medicine, UCLA Center for the Health Sciences, Los Angeles.
Footnotes
Accepted for publication Nov 9, 1978.
Reprint requests to Department of Medicine, UCLA Center for the Health Sciences, 10833 LeConte Ave, Los Angeles, CA 90024 (Dr Campisi).
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