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Effect of Parathyroidectomy on Anemia in Chronic Renal Failure
Galen L. Barbour, MD
Arch Intern Med. 1979;139(8):889-891.
Abstract
Fourteen patients with chronic renal failure underwent parathyroidectomy. Postoperatively, seven patients exhibited a rise in hematocrit reading, but seven others did not. Responders had more severe bone disease and lower initial hematocrit values than did nonresponders. Marrow fibrosis was slightly more prominent in responders. Current concepts of marrow erythropoietic inhibition in renal failure suggest a toxic serum factor as the cause. This report fails to support parathyroid hormone as the toxic agent directly responsible for marrow inh bition. Rather, parathyroid hormone may contribute to anemia in renal failure by causing marrow fibrosis, a process sometimes reversible by successful therapy of hyperparathyroidism.
(Arch Intern Med 139:889-891, 1979)
Author Affiliations
From the Renal Medicine Section, Department of Medicine, Veterans Administration Medical Center, and the University of Arkansas for Medical Sciences Campus, Little Rock.
Footnotes
Accepted for publication Feb 14, 1979.
Reprint requests to VA Medical Center, 300 E Roosevelt Rd, Little Rock, AK 72206 (Dr Barbour).
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