 |
|
Sleep-Induced Ventilatory Dysfunction in Down's Syndrome
Robert W. Clark, MD;
Helmut S. Schmidt, MD;
David E. Schuller, MD
Arch Intern Med. 1980;140(1):45-50.
Abstract
• Three patients with Down's syndrome demonstrated severe sleep-induced ventilatory failure characterized by Cheyne-Stokes respiration with superimposed obstruction of the upper airway. Anatomic otolaryngologic factors were present in two of the three patients, implicating both mechanical and CNS factors in the pathogenesis of this phenomenon. Administration of protriptyline hydrochloride elicited considerable improvement in one case. Occult sleep-related ventilatory failure may account for the previously unexplained tendency for pulmonary hypertension to develop in patients with Down's syndrome.
(Arch Intern Med 140:45-50, 1980)
Author Affiliations
From the Departments of Medicine (Neurology) (Dr Clark), Psychiatry (Drs Clark and Schmidt), and Otolaryngology (Dr Schuller), and the Ohio State University Sleep Disorders Evaluation Center (Drs Clark and Schmidt), Ohio State University College of Medicine, Columbus.
Footnotes
Accepted for publication April 6, 1979.
Reprints not available.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Prospective Polysomnographic Analysis of Obstructive Sleep Apnea in Down Syndrome
Dyken et al.
Arch Pediatr Adolesc Med 2003;157:655-660.
ABSTRACT
| FULL TEXT
Postoperative Complications After Tonsillectomy and Adenoidectomy in Children With Down Syndrome
Goldstein et al.
Arch Otolaryngol Head Neck Surg 1998;124:171-176.
ABSTRACT
| FULL TEXT
Alveolar Hypoventilation and Cor Pulmonale Associated with Chronic Airway Obstruction in Infants with Down Syndrome
Levine and Simpser
CLIN PEDIATR 1982;21:25-29.
ABSTRACT
|
