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Steven Ryder, MD; G. Murthy Gollapudi, MD, PhD; Andre Varma, MD

Arch Intern Med. 1980;140(10):1290-1291.

Abstract
• The relationship of serum thyroxine (T₄) and 3,5,3'-triiodothyronine (T₃) to the thyroid-stimulating hormone (TSH) response to protirelin was studied in 34 hypothyroid patients on a stable maintenance dose of oral levo-thyroxine. Release of TSH from the anterior pituitary, as measured by basal TSH and the TSH response to protirelin, correlated better with serum T₄ than serum T₃. Our study supports the concept that, in treated hypothyroid patients, serum T_, has a greater relative importance in mediating the actions of thyroid hormone on the anterior pituitary than serum T₃.

(Arch Intern Med 140:1290-1291, 1980)

Author Affiliations
From the Medical Service, Veterans Administration Medical Center (Drs Ryder and Gollapudi), Northport, NY; and the Department of Community and Preventive Medicine, State University of New York, Health Sciences Center (Dr Varma), Stonybrook.

Footnotes
Accepted for publication Oct 31, 1979.

Reprints not available.

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