This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (8)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Richard W. Baehler, MD; Jack Work, MD; William Smith, MD; Jerome A. Dominic, MD, PhD

Arch Intern Med. 1980;140(11):1466-1468.

Abstract
• Two patients suffered overdoses of anticonvulsant drugs. The first patient took methsuximide and the second, phenytoin. Because of profound CNS depression, both patients underwent hemoperfusion with a cellulose-activated charcoal hemoperfusion column. The primary metabolite of methsuximide, N-desmethylmethsuximide, primarily was responsible for the CNS depression in the first patient. The clearance of N-desmethylmethsuximide by the charcoal column was high, and clinical improvement became apparent during the hemoperfusion period. The clearance of phenytoin, on the other hand, was much lower than that of N-desmethylmethsuximide, and there was no apparent clinical improvement in that patient's condition.

(Arch Intern Med 140:1466-1468, 1980)

Author Affiliations
From the Medical Service, Veterans Administration Medical Center (Drs Baehler, Work, and Smith), and Department of Pharmacology, University of Kentucky Medical Center (Dr Dominic), Lexington.

Footnotes
Accepted for publication Dec 14, 1979.

Reprint requests to Dialysis Clinic, Inc, 1353 Leestown Rd, Lexington, KY 40511 (Dr Baehler).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?