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The Influence of Sodium Restriction on Orthostatic Sympathetic Nervous Activity
Usah Lilavivathana, MD;
Robert G. Campbell, MD
Arch Intern Med. 1980;140(11):1485-1489.
Abstract
• To evaluate the influence of low-salt diet on the sympathetic nervous system activity, the adaptation to upright posture in five normal subjects was studied during normal salt and 10-mEq sodium and 60-mEq potassium diets. On assuming upright posture, there were similar rises in pulse rate and diastolic blood pressure (BP) but a decline in systolic BP, during both diets. A prompt rise in plasma norepinephrine level during low-sodium diet was greater than during normal diet. Orthostatic response of the plasma epinephrine level was small, although significant, but unaffected by the diets. During normal-sodium diet, plasma renin activity response was delayed, but a prompt and enhanced response was observed during low-sodium diet. These data suggest that sodium deprivation enhances the sympathetic nervous system activity and the orthostatic stimulation of renin release.
(Arch Intern Med 140:1485-1489, 1980)
Author Affiliations
From the Endocrine-Metabolism Unit, Monroe Community Hospital, and the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY.
Footnotes
Accepted for publication Dec 10, 1979.
Reprint requests to Endocrine-Metabolism Unit, Monroe Community Hospital, 435 E Henrietta Rd, Rochester, NY 14603 (Dr Lilavivathana).
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