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Indirect Evidence of Phosphorus Uptake by Leukemic Cells

Kenneth W. Zamkoff, MD; Jeffrey J. Kirshner, MD

Arch Intern Med. 1980;140(11):1523-1524.

Abstract
• A 51-year-man was seen with the diagnosis of acute myelomonocytic leukemia. The WBC count was 380,000/µL at presentation. The serum phosphorus concentration was 0.4 mg/dL and 0.2 mg/dL prior to any phosphorus replacement. Urinary phosphorus excretion was too low to be measured. The patient did not demonstrate any of the usual causes of profound hypophosphatemia with hypophosphaturia. The parathyroid glands were normal at necropsy. Reasons for believing the profound hypophosphatemia was due to phosphorus uptake by the leukemic cells are discussed.

(Arch Intern Med 140:1523-1524, 1980)

Author Affiliations
From the Section of Hematology, Department of Medicine, Upstate Medical Center, Syracuse, NY, and the Syracuse (NY) Veterans Administration Medical Center.

Footnotes
Accepted for publication March 17, 1980.

Reprint requests to Section of Hematology, Upstate Medical Center, 750 E Adams St, Syracuse, NY 13210 (Dr Zamkoff).

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