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William J. Snape, Jr, MD; Mark A. Sullivan, MD; Sidney Cohen, MD

Arch Intern Med. 1980;140(3):386-387.

Abstract
• Gastrointestinal motility disturbances after endogenous stimuli have been demonstrated only in the esophagus and small intestine in patients with chronic idiopathic pseudo-obstruction. The 1,000-calorie meal stimulated a significant increase in spike and contractile activity in normal subjects. No increase in colonic spike or contractile activity occurred in patients with chronic idiopathic pseudo-obstruction even though colonic motility increased normally following the administration of neostigmine methylsulfate. These findings suggest that the normal response to eating is absent in patients with chronic idiopathic intestinal pseudo-obstruction even though their smooth muscle has been shown to be responsive to cholinergic stimulation. This loss of a gastrocolic response is further evidence for a disorder of the neurohumoral control mechanisms in patients with chronic idiopathic intestinal pseudo-obstruction.

(Arch Intern Med 140:386-387, 1980)

Author Affiliations
From the Gastrointestinal Section, Department of Medicine, University of Pennsylvania, Philadelphia.

Footnotes
Accepted for publication May 18, 1979.

Read in part before the national meeting of the American Federation for Clinical Research, Washington, DC, May 1, 1977.

Reprint requests to Gastrointestinal Section, Hospital of the University of Pennsylvania, 36th and Spruce Streets, Philadelphia, PA 19104 (Dr Snape).

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