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Granulomatous Hepatitis as a Manifestation of Quinidine Hypersensitivity
Dean A. Bramlet, MD;
Zoltan Posalaky, MD;
Robert Olson, MD
Arch Intern Med. 1980;140(3):395-397.
Abstract
Histologic pictures have been conflicting in previous cases of quinidine-associated hepatitis. We report a case of reversible granulomatous hepatitis from quinidine hypersensitivity, with granuloma induction occurring within three days after readministration of quinidine. Fever, urticaria, and mild thrombocytopenia were associated clinical findings. Both light and electron microscopic study results are reported.
(Arch Intern Med 140:395-397, 1980)
Author Affiliations
From the Departments of Internal Medicine (Drs Bramlet and Olson) and Pathology (Dr Posalaky), St Paul-Ramsey Medical Center, University of Minnesota Affiliated Hospitals, Minneapolis-St Paul. Dr Bramlet is now with Duke University Medical Center, Durham, NC.
Footnotes
Accepted for publication June 8, 1979.
Reprint requests to Department of Internal Medicine, Room 7035, St Paul-Ramsey Medical Center, St Paul, MN 55101 (Dr Bramlet).
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