 |
|
Renal Response to Potassium Loading in Sickle Cell Trait
James R. Oster, MD;
Douglas C. Lanier, Jr, MD;
Carlos A. Vaamonde, MD
Arch Intern Med. 1980;140(4):534-536.
Abstract
• Anatomical and functional renal medullary abnormalities are common in patients with sickle cell disease (HbSS) and sickle cell trait (HbAS). Sickle cell disease is associated with impaired urinary potassium excretion, but renal potassium handling in patients with HbAS has not been reported. To address this question, we gave nine HbAS and eight black control (HbAA) volunteers an oral potassium chloride load (0.75 mEq/kg of body weight), collected urine for five hours, and measured changes in the serum and urinary potassium levels. Both prior to and after potassium chloride loading, there were no differences between groups in serum or urinary potassium levels nor in percent of excretion of administered potassium. We conclude that patients with HbAS, despite decreased concentrating ability, have no impairment of the renal response to oral potassium loading and no apparent increased risk of hyperkalemia during periods of high potassium intake.
(Arch Intern Med 140:534-536, 1980)
Author Affiliations
From the Medical and Research Services, Veterans Administration Medical Center, and Department of Medicine, University of Miami (Fla) School of Medicine.
Footnotes
Accepted for publication June 29, 1979.
Reprint requests to Nephrology Section, VA Medical Center (111C1), 1201 NW 16th St, Miami, FL 33125 (Dr Oster).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Recursive estimation method for predicting residual bladder urine volumes to improve accuracy of timed urine collections
Afshartous and Preston
Stat Methods Med Res 2009;18:119-130.
ABSTRACT
|
