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James T. Frakes, MD

Arch Intern Med. 1980;140(5):620-623.

Abstract
• Therapy of ascites is important due to the significant morbidity and mortality to which this condition predisposes the cirrhotic patient. After briefly reviewing the pathogenesis of ascites to highlight the central role of sodium retention, the normal and altered physiology of salt and water balance are reviewed to provide a background for formulating a physiologic approach to medical management. Finally, a medical regimen for the management of ascites is suggested, one that employs salt and water restriction and a rational progressive program of diuretics to reverse the pathological sodium retention. Using such an approach, a high frequency of success with minimal complications can be achieved.

(Arch Intern Med 140:620-623, 1980)

Author Affiliations
From the School of Medicine, Department of Medicine, Division of Digestive Diseases and Nutrition, University of North Carolina, Chapel Hill.

Footnotes
Accepted for publication July 31, 1979.

Reprint requests to School of Medicine, Department of Medicine, Division of Digestive Diseases and Nutrition, University of North Carolina at Chapel Hill, Room 324, Clinical Sciences Bldg 229H, Chapel Hill, NC 27514 (Dr Frakes).

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