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Chronic Immunologic Thrombocytopenic PurpuraResults of Cyclophosphamide Therapy Before Splenectomy
Tanomsri Srichaikul, MD, MSc;
Somnate Boonpucknavig, MD;
Napaporn Archararit;
Watana Chaisiri-pumkeeree
Arch Intern Med. 1980;140(5):636-638.
Abstract
• Corticosteroids, cyclophosphamide, and splenectomy were employed in the treatment of 43 patients with immunologic thrombocytopenic purpura. All received corticosteroids initially; 22 patients received corticosteroids and cyclophosphamide, and six received drug treatment and underwent splenectomy. Of those receiving corticosteroids alone, 11 had excellent responses and ten had good responses. Of those receiving corticosteroids and cyclophosphamide, responses to treatment were excellent in six, good in eight, and fair in two. Of those receiving drug treatment and undergoing splenectomy, the responses to treatment were excellent in four, good in one, and fair in one. The duration required for induction of remission indicated the prognosis for patients; excellent responses were observed at 1, 2.4, and 4 months in groups treated, respectively, with corticosteroids, corticosteroids and cyclophosphamide, and drugs plus splenectomy.
(Arch Intern Med 140:636-638, 1980)
Author Affiliations
From the Department of Medicine, Faculty of Medicine, Ramathibodi Hospital (Dr Srichaikul, Ms Archararit, and Mr Chaisiri-pumkeeree), and Department of Pathobiology, Faculty of Sciences, Mahidol University (Dr Boonpucknavig), Bangkok, Thailand. Dr Srichaikul is presently with Vichaiyut Hospital, Bangkok.
Footnotes
Accepted for publication July 3, 1979.
Reprint requests to Vichaiyut Hospital, 114/4 Setsiri Rd, Bangkok, Thailand (Dr Srichaikul).
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