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Case Reports and a Recommended Approach

Lee Goldman, MD

Arch Intern Med. 1981;141(2):193-196.

Abstract
• Signs consistent with the propranolol withdrawal rebound syndrome may occur when propranolol hydrochloride administration is temporarily discontinued because of major noncardiac surgical procedures. The time course of the appearance of these signs indicates that the risk of the propranolol withdrawal rebound syndrome peaks about four to seven days after drug discontinuation. Continuation of propranolol up to the time of surgery appears safe from an anesthetic standpoint and may also help to postpone the risk of the withdrawal rebound syndrome until after oral propranolol therapy can be reinstituted.

(Arch Intern Med 141:193-196, 1981)

Author Affiliations
From the Divisions of Cardiology and General Medicine, Department of Medicine, Peter Bent Brigham Hospital, Boston.

Footnotes
Accepted for publication Feb 20, 1980.

Reprint requests to Division of General Medicine, Department of Medicine, Peter Bent Brigham Hospital, 721 Huntington Ave, Boston, MA 02115 (Dr Goldman).

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