This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Results From the Boston Collaborative Drug Surveillance Program

Hershel Jick, MD

Arch Intern Med. 1981;141(3):316-321.

Abstract
• All patients observed in this analysis of the Boston Collaborative Drug Surveillance Program data had no known disease predisposing them to gastrointestinal (GI) bleeding. Major GI bleeding occurred in hospitalized patients recently exposed to ethacrynic acid (5/111; 4.5%), heparin sodium (7/575; 1.2%), corticosteroids (7/1,484; 0.5%), aspirin (6/2,081; 0.3%), and warfarin sodium (1/423; 0.2%); combinations of two or more of these drugs also resulted in substantial incidences of bleeding. The rates for minor GI bleeding in hospitalized patients varied from 8.3% for heparin to 1.6% for aspirin. In outpatients admitted because of serious GI bleeding, 14/88 (16%) had a history of heavy, regular aspirin use compared with 1,015/14,813 (6.9%) control subjects admitted for other reasons (relative risk, 2.1). No association between light regular use of aspirin and GI bleeding was noted. No association between the use of acetaminophen and GI bleeding was noted in any of the patients studied.

(Arch Intern Med 1981;141:316-321)

Author Affiliations
From the Department of Medicine, Boston University School of Medicine, and the Boston Collaborative Drug Surveillance Program, Waltham, Mass.

Footnotes
Reprint requests to the Boston Collaborative Drug Surveillance Program, 400 Totten Pond Rd, Waltham, MA 02154 (Dr Jick).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Striking Prevalence of Over-the-Counter Nonsteroidal Anti-inflammatory Drug Use in Patients With Upper Gastrointestinal Hemorrhage
Wilcox et al.
Arch Intern Med 1994;154:42-46.
ABSTRACT  

Nonsteroidal Anti-inflammatory Drug Gastropathy: Recognition and Response
Roth and Bennett
Arch Intern Med 1987;147:2093-2100.
ABSTRACT  

Aspirin and the Stomach
GRAHAM and SMITH
ANN INTERN MED 1986;104:390-398.
ABSTRACT