 |
|
Extracorporeal Treatment of Salicylate or Acetaminophen Poisoning—Is There a Role?
James F. Winchester, MB, MRCP;
Michael C. Gelfand, MD;
Michael Helliwell, MB, MRCP;
John Allister Vale, MB, MRCP;
Roy Goulding, BSc, MD, FRCP, FRCPath;
George E. Schreiner, MD
Arch Intern Med. 1981;141(3):370-374.
Abstract
• Hemodialysis or sorbent hemoperfusion has been used in the management of clinical overdose of salicylates or acetaminophen. Hemodialysis offers considerable benefit in severe salicylate poisoning and is preferred to hemoperfusion or peritoneal dialysis, since it more rapidly corrects acid-base and electrolyte abnormalities than does hemoperfusion, and since it is clearly more efficient than is peritoneal dialysis for the removal of salicylates. Charcoal hemoperfusion in animal studies and hemodialysis in man have been shown to accelerate acetaminophen elimination from the body. Hemodialysis and hemoperfusion are of questionable benefit in clinical acetaminophen overdose. However, our clinical experience to date with charcoal hemoperfusion in "late" acetaminophen overdose has been associated with a less notable increase in liver enzyme concentrations in comparison with results of retrospective studies of series of patients treated or not treated with sulfhydryl donors.
(Arch Intern Med 1981;141:370-374)
Author Affiliations
From the Department of Medicine, Division of Nephrology, Georgetown University Hospital, Washington, DC (Drs Winchester, Gelfand, and Schreiner), and the Poisons Unit, Guy's Hospital, London (Drs Goulding, Helliwell, and Vale).
Footnotes
Reprint requests to the Department of Medicine, Division of Nephrology, 503 Kober Cogan Bldg, Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC 20007 (Dr Winchester).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Three case reports of the use of haemodiafiltration in the treatment of salicylate overdose
Wrathall et al.
Hum Exp Toxicol 2001;20:491-495.
ABSTRACT
Refractory Hypoglycemia Secondary to Topical Salicylate Intoxication
Raschke et al.
Arch Intern Med 1991;151:591-593.
ABSTRACT
Does Multiple-Dose Charcoal Therapy Enhance Salicylate Excretion?
Kirshenbaum et al.
Arch Intern Med 1990;150:1281-1283.
ABSTRACT
A Two-Year Review of Salicylate Deaths in Ontario
McGuigan
Arch Intern Med 1987;147:510-512.
ABSTRACT
|
