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Richard S. Muther, MD; David A. McCarron, MD; William M. Bennett, MD

Arch Intern Med. 1981;141(5):643-645.

Abstract
• Sarcoidosis may involve the kidneys in several ways. Most commonly, aberrations of calcium metabolism, including hypercalcemia, hypercalciuria, and nephrocalcinosis, are responsible for the renal manifestations of sarcoidosis. Granulomatous infiltration of the renal interstitium may also produce severe derangements of renal function. Glomerulonephritis can occur with sarcoidosis, although the pathogenesis remains unclear. Besides renal insufficiency and frank renal failure, nephrotic syndrome, nephrolithiasis, hypertension, and a variety of tubular defects may complicate sarcoidosis. The sensitivity of "sarcoid nephropathy" to corticosteroids usually warrants a therapeutic trial.

(Arch Intern Med 1981;141:643-645)

Author Affiliations
From the Division of Nephrology, University of Oregon Health Sciences Center, Portland, and the Portland Veterans Administration Hospital.

Footnotes
Accepted for publication March 7, 1980.

Reprint requests to Division of Nephrology, University of Oregon Health Sciences Center, 3181 SW Sam Jackson Park Rd, Portland, OR 97201 (Dr McCarron).

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