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Recurrent Pseudomembranous Colitis Unassociated With Prior Antibiotic Therapy
Morry Moskovitz, MD;
John G. Bartlett, MD
Arch Intern Med. 1981;141(5):663-664.
Abstract
• Fulminant and recurring pseudomembranous colitis developed in an elderly woman without prior antibiotic administration within the previous year. Stool culture yielded Clostridium difficile, and tissue cultures showed C difficile cytotoxin. Treatment with vancomycin hydrochloride was initially successful, but a serious relapse after its discontinuation necessitated low-dose long-term prophylaxis. Clostridium difficile may be responsible for pseudomembranous colitis unassociated with antibiotic therapy.
(Arch Intern Med 1981;141:663-664)
Author Affiliations
From the Medical Center of Beaver County, Rochester, Pa (Dr Moskovitz), and the Veterans Administration Medical Center and Tufts University School of Medicine, Boston (Dr Bartlett).
Footnotes
Accepted for publication April 28, 1980.
Reprint requests to 336 College Ave, Beaver, PA 15009 (Dr Moskovitz).
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