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Its Use in the Follow-up of Diabetes and Diagnosis of Glucose Intolerance

Arye Lev-Ran, MD, PhD

Arch Intern Med. 1981;141(6):747-749.

Abstract
In 140 persons with a normal glucose tolerance test (GTT), the median glycohemoglobin (GHb) level was 8.1% (95% limits, 6.5% to 9.0%). The GHb level was not significantly different in 30 patients with impaired GTT (8.6%). In all 14 patients with diabetic GTT and fasting plasma glucose (PG) level above 140 mg/dL, GHb level was above 10% (median, 11.3%). Of 25 patients with diabetic GTT but without fasting hyperglycemia, only two had GHb levels 10% or above. The GHb level correlated with the mean daily PG level in both 176 insulin-dependent (r_S, +.530) and 107 non-insulin-dependent (r_S, +.734) diabetics. Correlation was almost zero between GHb level and mean one-day PG level in 14 most brittle insulin-dependent diabetics. However, in them, there was a strong correlation (r_S, +.763) between GHb level and the mean of 20 or more PG values for the preceding month. Follow-up of 100 diabetics showed strong correlation (r_S, +.845) between the changes in GHb level and in the mean PG level. Decrease of the mean PG level of 100 mg/dL was accompanied by a drop of the GHb level of about 2%.

(Arch Intern Med 1981;141:747-749)

Author Affiliations
From the Division of Diabetes and Endocrinology, Departments of Medicine and Clinical Research, Scripps Clinic and Research Foundation, La Jolla, Calif.

Footnotes
Accepted for publication April 28, 1980.

Reprint requests to Scripps Clinic, La Jolla, CA 92037 (Dr Lev-Ran).

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