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Matthew R. Pincus, MD, PhD; Margarita Silva-Hutner, PhD; Gladys Rebatta; A. Whitley Branwood, MD

Arch Intern Med. 1981;141(6):796-797.

Abstract
• Widely disseminated cryptococcosis was found on autopsy in a 50-year-old alcoholic man. The spleen, lungs, CNS, liver, kidney, and lymph nodes were all involved. In his clinical course, the patient showed no signs of immunologic anergy. His terminal hospital course resulted directly from end-stage liver disease and renal failure. The cryptococcal infection was of the nongranulomatous, diffuse type with little or no inflammatory response, which probably explains the lack of symptoms.

(Arch Intern Med 1981;141:796-797)

Author Affiliations
From the Departments of Pathology (Drs Pincus and Branwood), Dermatology (Dr Silva-Hutner), and Mycology (Ms Rebatta), Columbia Presbyterian Medical Center, New York. Dr Pincus is now with the National Cancer Institute, Bethesda, Md.

Footnotes
Accepted for publication April 7, 1980.

Reprint requests to Laboratory of Theoretical Biology, National Cancer Institute, Bldg 10, Room 4B56, National Institutes of Health, Bethesda, MD 20205 (Dr Pincus).

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