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Plasma Thromboplastin Antecedent (Factor XI) Deficiency in a Black Family
Eero O. Niskanen, MD, PhD;
Hidehiko Saito, MD;
Martin J. Cline, MD
Arch Intern Med. 1981;141(7):936-937.
Abstract
• A black man with a prolonged partial thromboplastin time had a severe deficiency of plasma thromboplastin antecedent (PTA) (factor XI) measured both in clotting assays and immunoassays, suggesting a diagnosis of homozygous PTA deficiency. His offspring seemed to be heterozygous carriers of PTA deficiency. Additionally, the proband and two of his children had decreased Hageman factor (factor XII) levels consistent with those of heterozygous carriers of Hageman trait. To our knowledge, this is the first case known of PTA deficiency in a black person. Its pattern of inheritance was independent of that of factor XII deficiency.
(Arch Intern Med 1981;141:936-937)
Author Affiliations
From the Division of Hematology-Oncology, Department of Medicine (Drs Niskanen and Cline) UCLA School of Medicine, Los Angeles; Department of Medicine (Dr Saito), University Hospitals of Cleveland, Cleveland; and the Division of Hematology-Oncology, Department of Internal Medicine (Dr Niskanen), University of Virginia School of Medicine, Charlottesville.
Footnotes
Accepted for publication May 11, 1980.
Reprint requests to Department of Internal Medicine, Box 502, University of Virginia School of Medicine, Charlottesville, VA 22908 (Dr Niskanen).
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