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Hypothyroidism, Triiodothyronine Antibodies, and Hyperprolactinemia
Robert R. Henry, MD;
Francisco I. Reyes, MD, FRCS(C);
Charles Faiman, MD, FRCP(C)
Arch Intern Med. 1981;141(7):953-955.
Abstract
• This report describes the development of triiodothyronine (T3) antibodies in a patient with Hashimoto's thyroiditis that resulted in compensated hypothyroidism and hyperprolactinemia. The patient, a 23-year-old woman, had a small goiter, modest elevation of thyrotropin (TSH) and prolactin (PRL) levels, and a markedly elevated T3 level. Circulating antibodies to T3 were demonstrated that presumably rendered the T, physiologically inactive. Saturation of antibody binding sites by incremental dosages of liothyronine (triiodothyronine) sodium (12.5 to 87.5 µg/day) resulted in normalization of both the TSH and PRL levels.
(Arch Intern Med 1981;141:953-955)
Author Affiliations
From the Departments of Medicine (Drs Henry and Faiman), Obstetrics and Gynaecology (Dr Reyes), and Physiology (Dr Faiman), University of Manitoba, and the Endocrine-Metabolism Laboratory, Health Sciences Centre, Winnipeg, Manitoba, Canada.
Footnotes
Accepted for publication April 28, 1980.
Reprint requests to Health Sciences Centre, 700 William Ave, Winnipeg, Manitoba, R3E 0Z3 Canada (Dr Faiman).
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