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The State of the Art

Paul Wolf, MD; Diane Reid, MD

Arch Intern Med. 1981;141(8):1067-1070.

Abstract
• The previous uses of tumor-associated markers were to detect neoplasms early, before they had metastasized, and to monitor their treatment. Recently, antibodies to these tumorassociated markers have been radiolabeled, and the radiolabeled antibodies have been used to localize the neoplasms by external scintillation imaging. Potential now exists for treatment of the neoplasm by combining radiotherapeutic agents with the monoclonal antibodies to the neoplasm and infusing the patient with this combination. Three tumor-associated markers that are most often used are -fetoprotein, carcinoembryonic antigen, and human chorionic gonadotropin β-subunit. In addition, recently developed tumor-associated marker enzymes include galactosyl transferase isoenzyme II, creatine kinase BB, and radioimmunoassay of prostatic acid phosphatase isoenzyme.

(Arch Intern Med 1981;141:1067-1070)

Author Affiliations
From the Department of Pathology, University of California, School of Medicine, La Jolla (Dr Wolf), and Department of Medicine, University of Washington, School of Medicine, Seattle (Dr Reid).

Footnotes
Accepted for publication May 12, 1980.

Reprint requests to University of California, Medical Center, 225 Dickinson St, San Diego, CA 92103 (Dr Wolf).

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