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Invasive Fungal Infections in Patients With Chronic Mucocutaneous Candidiasis
Carol A. Kauffman, MD;
Michael J. Shea, MD;
Peter T. Frame, MD
Arch Intern Med. 1981;141(8):1076-1078.
Abstract
• Patients with chronic mucocutaneous candidiasis have persistent Candida infection of nails, skin, and mucous membranes, but rarely, if ever, does an invasive fungal infection develop. We describe two patients with chronic mucocutaneous candidiasis who died of fungal infection; one had C albicans meningitis and the second had Cryptococcus neolormans meningitis. The cases of four other patients with chronic mucocutaneous candidiasis and invasive fungal infection, three with crytococcosis and one with histoplasmosis, have been reported previously. Immunological profiles on these six patients revealed no differences from those of other patients with chronic mucocutaneous candidiasis without invasive fungal infection. Three of the four patients who received amphotericin B were cured of their infection; three patients died, including one patient with overwhelming cryptococcosis who had received intensive antifungal therapy and transfer factor.
(Arch Intern Med 1981;141:1076-1078)
Author Affiliations
From the Departments of Internal Medicine, University of Michigan Medical School and Ann Arbor (Mich) Veterans Administration Medical Center (Drs Kauffman and Shea), and the University of Cincinnati Medical School (Dr Frame).
Footnotes
Accepted for publication June 16, 1980.
Reprint requests to Medical Service, Veterans Administration Medical Center, Ann Arbor, MI 48105 (Dr Kauffman).
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