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Plasma Thyronine Levels in Carcinoma of the Breast and Colon
David P. Rose, MD, PhD;
Thomas E. Davis, MD
Arch Intern Med. 1981;141(9):1161-1164.
Abstract
Plasma triiodothyronine (T3), reverse T3 (rT3), thyroxine (T4), total thyroid hormone-binding globulin (TBG) capacity, and serum albumin were assayed in patients with early and advanced breast and colonic cancer and in healthy women. Plasma T3 levels were reduced in both breast cancer groups, but were reduced only in colonic cancer patients with systemic metastases. Plasma rT3 was normal in early cancer, but increased in nine of 38 (24%) with advanced breast cancer and four of 17 (24%) with metastatic colonic cancer; in consequence their rT3/T3 ratios were elevated. Plasma T4 concentrations were normal in all patient groups. Plasma TBG capacity was reduced in breast cancer patients with systemic metastases and a similar tendency occurred in metastatic colonic cancer. Levels of TBG were positively correlated with the serum albumin values. These changes were associated particularly with liver metastases.
(Arch Intern Med 1981;141:1161-1164)
Author Affiliations
From the Division of Clinical Oncology, Wisconsin Clinical Cancer Center, University of Wisconsin Medical School, Madison.
Footnotes
Accepted for publication July 29, 1980.
Reprint requests to Wisconsin Clinical Cancer Center, K4/628, Clinical Sciences Center, 600 Highland Ave, Madison, WI 53792 (Dr Rose).
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