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Joel Greenspan, MD; James T. Noble, MD; Marvin J. Tenenbaum, MD

Arch Intern Med. 1981;141(9):1222-1223.

Abstract
• Haemophilus parainfluenzae is an increasingly reported cause of infective endocarditis. In vitro studies have shown this organism to be almost universally sensitive to chloramphenicol. However, therapy for H parainfluenzae endocarditis with chloramphenicol as a single agent has been disappointing. This has been attributed to the bacteriostatic activity of chloramphenicol, whereas bactericidal agents are essential for cure of infective endocarditis. We successfully treated a patient with H parainfluenzae endocarditis with chloramphenicol alone after in vitro testing showed chloramphenicol to be bactericidal against the organism. When it is documented that chloramphenicol has bactericidal activity against the causative organism, it alone can be effective therapy for H parainfluenzae endocarditis.

(Arch Intern Med 1981;141:1222-1223)

Author Affiliations
From the Division of Infectious Disease and Immunology, Department of Medicine, North Shore University Hospital, Manhasset, NY; and the Department of Medicine, Cornell University Medical College, New York. Dr Noble is now with Tufts University Medical Center, Medford, Mass.

Footnotes
Accepted for publication July 29, 1980.

Reprint requests to the Division of Infectious Disease and Immunology, Department of Medicine, North Shore University Hospital, 300 Community Dr, Manhasset, NY 11030 (Dr Tenenbaum).

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